Formalin evokes calcium transients from the endoplasmatic reticulum.

Formalin evokes calcium transients from the endoplasmatic reticulum.

The formalin test is the most widely used behavioral screening test for analgesic compounds. The cellular mechanism of action of formaldehyde, inducing a typically biphasic pain-related behavior in rodents is addressed in this study. The chemoreceptor channel TRPA1 was suggested as primary transduce...

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Bibliographic Details
Main Authors: Michael J M Fischer, Kailey J Soller, Susanne K Sauer, Joanna Kalucka, Gianluigi Veglia, Peter W Reeh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4398422?pdf=render

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