Vulnerability and resilience to Alzheimer’s disease: early life conditions modulate neuropathology and determine cognitive reserve

Vulnerability and resilience to Alzheimer’s disease: early life conditions modulate neuropathology and determine cognitive reserve

Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a high prevalence among the elderly and a huge personal and societal impact. Recent epidemiological studies have indicated that the incidence and age of onset of sporadic AD can be modified by lifestyle fac...

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Bibliographic Details
Main Authors: Sylvie L. Lesuis, Lianne Hoeijmakers, Aniko Korosi, Susanne R. de Rooij, Dick F. Swaab, Helmut W. Kessels, Paul J. Lucassen, Harm J. Krugers
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Alzheimer’s Research & Therapy
Subjects:
Resilience
Vulnerability
Early life
Stress
Neonatal handling
Hypothalamic–pituitary–adrenal axis
Online Access:http://link.springer.com/article/10.1186/s13195-018-0422-7

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