Comparative investigation of dimephosphon, actovegin and trental influence on survival potention of skin-fascial autograft in arterial blood insufficiency and venous stasis

• Main Authors: D. A. Nefedov, A. V. Zelenskaya, V. V. Kopitza, O. Y. Timakova, Y. A. Khananashvily, P. A. Galenko-Yaroshevsky
• Format: Article
• Language: Russian
• Published: Ministry of Healthcare of the Russian Federation. “Kuban State Medical University” 2016-06-01
• Series: Кубанский научный медицинский вестник
• Subjects: несвободный кожно-фасциальный аутотрансплантат; димефосфон; актовегин; трентал; дерматопротекторное действие; constrained skin-fascial autograft; dimephosfon; aktovegin; trental; dermaprotective action
• Online Access: https://ksma.elpub.ru/jour/article/view/531
• ISSN: 1608-6228; 2541-9544

It has been demonstrated that dimephosphon as well as actovegin and trental taken for the comparison in conditions of the «normal» (АВВА) arterialvenous permeability, «separated» (АВВА and АВВА; the underlined letters here and further denote the ligation of arteries and veins in different variants) and «mixed» (АВВА, АВВА, АВВА и АВВА) arterial and venous insuffieciency of the constrained skin-fascial autograft (on two feeding cruses with preserved skin sensitive nerves) increase its survival potential. On intensity of dermaprotective action (DPA) dimephosfon and reference preparations can be situated as following: АВВА - trental > dimephosphon = actovegin; АВВА - dimephosphon = trental > actovegin; АВВА - actovegin = dimephosphon, trental is not effective; АВВА - dimephosphon = actovegin = trental; АВВА - all these preparations are not effective; АВВА - trental > dimephosphon = actovegin. The DPA mechanism of dimephosphon depends on its ability to join in the different links of homeostasis and mediately to provide the functional correction of violated local (myogenic and metabolic) and remote neurohormonal mechanisms that regulate blood flow to the skin.