CRISPR-Based Activation of Endogenous Expression of TPM1 Inhibits Inflammatory Response of Primary Human Coronary Artery Endothelial and Smooth Muscle Cells Induced by Recombinant Human Tumor Necrosis Factor α

CRISPR-Based Activation of Endogenous Expression of TPM1 Inhibits Inflammatory Response of Primary Human Coronary Artery Endothelial and Smooth Muscle Cells Induced by Recombinant Human Tumor Necrosis Factor α

Tumor necrosis factor α (TNFα) is one of the most important proinflammatory cytokines, which affects many processes associated with the growth and characteristics of endothelial, smooth muscle, and immune system cells. However, there is no correlation between most in vivo and in vitro studies on its...

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Bibliographic Details
Main Authors: Maciej Gagat, Wioletta Zielińska, Klaudia Mikołajczyk, Jan Zabrzyński, Adrian Krajewski, Anna Klimaszewska-Wiśniewska, Dariusz Grzanka, Alina Grzanka
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TNFα
endothelial cells
angiogenesis
F-actin
cell–cell junctions
cell adhesion
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.668032/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.668032/full

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