| Summary: | Objective: To study the PD-1 and PD-1L expression in peripheral blood T lymphocytes of
patients with chronic periodontitis and their correlation with the degree of inflammation.
Methods: A total of 58 patients diagnosed with chronic periodontitis and 50 healthy volunteers
receiving physical examination in our hospital between May 2012 and October 2015 were
selected as the periodontitis group and the control group of the study respectively, the
peripheral blood was collected to determine the PD-1 and PD-1L expression in T lymphocytes,
and the gingival crevicular fluid and serum were determined to determine the content of
inflammatory cytokines, adhesion molecules and protease molecules. Results: PD-1 and PD-
1L fluorescence intensity on peripheral blood CD4+T lymphocyte and CD8+T lymphocyte
surface of periodontitis group were significantly higher than those of control group, and IL-1
β, IL-8, TNF-α, sICAM-1, sVCAM-1, MMP-1, MMP-7 and MMP-13 content in serum and
gingival crevicular fluid were significantly higher than those of control group; PD-1 and PD-
1L fluorescence intensity on peripheral blood CD4+T lymphocyte and CD8+T lymphocyte
surface were positively correlated with IL-1β, IL-8, TNF-α, sICAM-1, sVCAM-1, MMP-1,
MMP-7 and MMP-13 content in serum and gingival crevicular fluid. Conclusion: Highly
expressed PD-1 and PD-1L in the peripheral blood T lymphocytes of patients with chronic
periodontitis can enhance the inflammatory response and promote the alveolar bone resorption
and destruction through negative immunomodulatory effect.
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