Investigation of α-Synuclein Amyloid Fibrils Using the Fluorescent Probe Thioflavin T

Investigation of α-Synuclein Amyloid Fibrils Using the Fluorescent Probe Thioflavin T

In this work, α-synuclein amyloid fibrils—the formation of which is a biomarker of Parkinson’s disease—were investigated using the fluorescent probe thioflavin T (ThT). The experimental conditions of protein fibrillogenesis were chosen so that a sufficient num...

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Bibliographic Details
Main Authors: Anna I. Sulatskaya, Natalia P. Rodina, Maksim I. Sulatsky, Olga I. Povarova, Iuliia A. Antifeeva, Irina M. Kuznetsova, Konstantin K. Turoverov
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein
amyloid fibrils
fibrillogenesis
thioflavin T
equilibrium microdialysis
binding parameters
structural polymorphism
Online Access:http://www.mdpi.com/1422-0067/19/9/2486

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http://www.mdpi.com/1422-0067/19/9/2486

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