Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models

Obesity and its associated metabolic changes, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Here, the authors show that restricting when mice eat, but not what or how much they eat, delays breast cancer...

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Main Authors:	Manasi Das, Lesley G. Ellies, Deepak Kumar, Consuelo Sauceda, Alexis Oberg, Emilie Gross, Tyler Mandt, Isabel G. Newton, Mehak Kaur, Dorothy D. Sears, Nicholas J. G. Webster
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20743-7

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spelling	doaj-a2944ae436f340f4a94b7c20729f5a092021-01-31T12:19:55ZengNature Publishing GroupNature Communications2041-17232021-01-0112111910.1038/s41467-020-20743-7Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse modelsManasi Das0Lesley G. Ellies1Deepak Kumar2Consuelo Sauceda3Alexis Oberg4Emilie Gross5Tyler Mandt6Isabel G. Newton7Mehak Kaur8Dorothy D. Sears9Nicholas J. G. Webster10VA San Diego Healthcare SystemDepartment of Pathology, University of California San DiegoVA San Diego Healthcare SystemVA San Diego Healthcare SystemVA San Diego Healthcare SystemVA San Diego Healthcare SystemDepartment of Radiology, University of California, San DiegoDepartment of Radiology, University of California, San DiegoDepartment of Medicine, Division of Endocrinology and Metabolism, University of California San DiegoDepartment of Medicine, Division of Endocrinology and Metabolism, University of California San DiegoVA San Diego Healthcare SystemObesity and its associated metabolic changes, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Here, the authors show that restricting when mice eat, but not what or how much they eat, delays breast cancer initiation and reduces tumor growth in obese mice in addition to improving insulin sensitivity and restoring circadian rhythms.https://doi.org/10.1038/s41467-020-20743-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Manasi Das Lesley G. Ellies Deepak Kumar Consuelo Sauceda Alexis Oberg Emilie Gross Tyler Mandt Isabel G. Newton Mehak Kaur Dorothy D. Sears Nicholas J. G. Webster
spellingShingle	Manasi Das Lesley G. Ellies Deepak Kumar Consuelo Sauceda Alexis Oberg Emilie Gross Tyler Mandt Isabel G. Newton Mehak Kaur Dorothy D. Sears Nicholas J. G. Webster Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models Nature Communications
author_facet	Manasi Das Lesley G. Ellies Deepak Kumar Consuelo Sauceda Alexis Oberg Emilie Gross Tyler Mandt Isabel G. Newton Mehak Kaur Dorothy D. Sears Nicholas J. G. Webster
author_sort	Manasi Das
title	Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
title_short	Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
title_full	Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
title_fullStr	Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
title_full_unstemmed	Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
title_sort	time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	Obesity and its associated metabolic changes, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Here, the authors show that restricting when mice eat, but not what or how much they eat, delays breast cancer initiation and reduces tumor growth in obese mice in addition to improving insulin sensitivity and restoring circadian rhythms.
url	https://doi.org/10.1038/s41467-020-20743-7
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Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models

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