Comparisons of different mean airway pressure settings during high-frequency oscillation in inflammatory response to oleic acid-induced lung injury in rabbits

Koichi Ono1, Tomonobu Koizumi2, Rikimaru Nakagawa1, Sumiko Yoshikawa2, Tetsutarou Otagiri11Department of Anesthesiology and Resuscitation; 2First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, JapanPurpose: The present study was designed to examine effects of diff...

Full description

Bibliographic Details
Main Authors: Koichi Ono, Tomonobu Koizumi, Rikimaru Nakagawa, Sumiko Yoshikawa, Tetsutarou Otagiri
Format: Article
Language:English
Published: Dove Medical Press 2009-03-01
Series:Journal of Inflammation Research
Online Access:http://www.dovepress.com/comparisons-of-different-mean-airway-pressure-settings-during-high-fre-a2953
id doaj-a28c434b38a749c2b3d265d17f5be5b4
record_format Article
spelling doaj-a28c434b38a749c2b3d265d17f5be5b42020-11-24T23:36:44ZengDove Medical PressJournal of Inflammation Research1178-70312009-03-012009default2128Comparisons of different mean airway pressure settings during high-frequency oscillation in inflammatory response to oleic acid-induced lung injury in rabbitsKoichi OnoTomonobu KoizumiRikimaru NakagawaSumiko YoshikawaTetsutarou OtagiriKoichi Ono1, Tomonobu Koizumi2, Rikimaru Nakagawa1, Sumiko Yoshikawa2, Tetsutarou Otagiri11Department of Anesthesiology and Resuscitation; 2First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, JapanPurpose: The present study was designed to examine effects of different mean airway pressure (MAP) settings during high-frequency oscillation (HFO) on oxygenation and inflammatory responses to acute lung injury (ALI) in rabbits.Methods: Anesthetized rabbits were mechanically ventilated with a conventional mechanical ventilation (CMV) mode (tidal volume 6 ml/kg, inspired oxygen fraction [FIo2] of 1.0, respiratory rate [RR] of 30/min, positive end-expiratory pressure [PEEP] of 5 cmH2O). ALI was induced by intravenous administration of oleic acid (0.08 ml/kg) and the animals were randomly allocated to the following three experimental groups; animals (n = 6) ventilated using the same mode of CMV, or animals ventilated with standard MAP (MAP 10 cmH2O, n = 7), and high MAP (15 cmH2O, n = 6) settings of HFO (Hz 15). The MAP settings were calculated by the inflation limb of the pressure-volume curve during CMV.Results: HFO with a high MAP setting significantly improved the deteriorated oxygenation during oleic acid-induced ALI and reduced wet/dry ratios, neutrophil counts and interleukin-8 concentration in bronchoalveolar lavage fluid, compared to those parameters in CMV and standard MAP-HFO.Conclusions: These findings suggest that only high MAP setting during HFO could contribute to decreased lung inflammation as well as improved oxygenation during the development of ALI.Keywords: lung protective ventilation, open lung ventilation, IL-8, neutrophil http://www.dovepress.com/comparisons-of-different-mean-airway-pressure-settings-during-high-fre-a2953
collection DOAJ
language English
format Article
sources DOAJ
author Koichi Ono
Tomonobu Koizumi
Rikimaru Nakagawa
Sumiko Yoshikawa
Tetsutarou Otagiri
spellingShingle Koichi Ono
Tomonobu Koizumi
Rikimaru Nakagawa
Sumiko Yoshikawa
Tetsutarou Otagiri
Comparisons of different mean airway pressure settings during high-frequency oscillation in inflammatory response to oleic acid-induced lung injury in rabbits
Journal of Inflammation Research
author_facet Koichi Ono
Tomonobu Koizumi
Rikimaru Nakagawa
Sumiko Yoshikawa
Tetsutarou Otagiri
author_sort Koichi Ono
title Comparisons of different mean airway pressure settings during high-frequency oscillation in inflammatory response to oleic acid-induced lung injury in rabbits
title_short Comparisons of different mean airway pressure settings during high-frequency oscillation in inflammatory response to oleic acid-induced lung injury in rabbits
title_full Comparisons of different mean airway pressure settings during high-frequency oscillation in inflammatory response to oleic acid-induced lung injury in rabbits
title_fullStr Comparisons of different mean airway pressure settings during high-frequency oscillation in inflammatory response to oleic acid-induced lung injury in rabbits
title_full_unstemmed Comparisons of different mean airway pressure settings during high-frequency oscillation in inflammatory response to oleic acid-induced lung injury in rabbits
title_sort comparisons of different mean airway pressure settings during high-frequency oscillation in inflammatory response to oleic acid-induced lung injury in rabbits
publisher Dove Medical Press
series Journal of Inflammation Research
issn 1178-7031
publishDate 2009-03-01
description Koichi Ono1, Tomonobu Koizumi2, Rikimaru Nakagawa1, Sumiko Yoshikawa2, Tetsutarou Otagiri11Department of Anesthesiology and Resuscitation; 2First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, JapanPurpose: The present study was designed to examine effects of different mean airway pressure (MAP) settings during high-frequency oscillation (HFO) on oxygenation and inflammatory responses to acute lung injury (ALI) in rabbits.Methods: Anesthetized rabbits were mechanically ventilated with a conventional mechanical ventilation (CMV) mode (tidal volume 6 ml/kg, inspired oxygen fraction [FIo2] of 1.0, respiratory rate [RR] of 30/min, positive end-expiratory pressure [PEEP] of 5 cmH2O). ALI was induced by intravenous administration of oleic acid (0.08 ml/kg) and the animals were randomly allocated to the following three experimental groups; animals (n = 6) ventilated using the same mode of CMV, or animals ventilated with standard MAP (MAP 10 cmH2O, n = 7), and high MAP (15 cmH2O, n = 6) settings of HFO (Hz 15). The MAP settings were calculated by the inflation limb of the pressure-volume curve during CMV.Results: HFO with a high MAP setting significantly improved the deteriorated oxygenation during oleic acid-induced ALI and reduced wet/dry ratios, neutrophil counts and interleukin-8 concentration in bronchoalveolar lavage fluid, compared to those parameters in CMV and standard MAP-HFO.Conclusions: These findings suggest that only high MAP setting during HFO could contribute to decreased lung inflammation as well as improved oxygenation during the development of ALI.Keywords: lung protective ventilation, open lung ventilation, IL-8, neutrophil
url http://www.dovepress.com/comparisons-of-different-mean-airway-pressure-settings-during-high-fre-a2953
work_keys_str_mv AT koichiono comparisonsofdifferentmeanairwaypressuresettingsduringhighfrequencyoscillationininflammatoryresponsetooleicacidinducedlunginjuryinrabbits
AT tomonobukoizumi comparisonsofdifferentmeanairwaypressuresettingsduringhighfrequencyoscillationininflammatoryresponsetooleicacidinducedlunginjuryinrabbits
AT rikimarunakagawa comparisonsofdifferentmeanairwaypressuresettingsduringhighfrequencyoscillationininflammatoryresponsetooleicacidinducedlunginjuryinrabbits
AT sumikoyoshikawa comparisonsofdifferentmeanairwaypressuresettingsduringhighfrequencyoscillationininflammatoryresponsetooleicacidinducedlunginjuryinrabbits
AT tetsutarouotagiri comparisonsofdifferentmeanairwaypressuresettingsduringhighfrequencyoscillationininflammatoryresponsetooleicacidinducedlunginjuryinrabbits
_version_ 1725521780332822528