Lipid Transporters Beam Signals from Cell Membranes
Lipid composition in cellular membranes plays an important role in maintaining the structural integrity of cells and in regulating cellular signaling that controls functions of both membrane-anchored and cytoplasmic proteins. ATP-dependent ABC and P4-ATPase lipid transporters, two integral membrane...
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2021-07-01
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doaj-a284a6c7452445f084641aacc7097d4a2021-08-26T14:03:17ZengMDPI AGMembranes2077-03752021-07-011156256210.3390/membranes11080562Lipid Transporters Beam Signals from Cell MembranesMiliça Ristovski0Danny Farhat1Shelly Ellaine M. Bancud2Jyh-Yeuan Lee3Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaLipid composition in cellular membranes plays an important role in maintaining the structural integrity of cells and in regulating cellular signaling that controls functions of both membrane-anchored and cytoplasmic proteins. ATP-dependent ABC and P4-ATPase lipid transporters, two integral membrane proteins, are known to contribute to lipid translocation across the lipid bilayers on the cellular membranes. In this review, we will highlight current knowledge about the role of cholesterol and phospholipids of cellular membranes in regulating cell signaling and how lipid transporters participate this process.https://www.mdpi.com/2077-0375/11/8/562P4-ATPaseABC transporterphospholipidcholesterolmembranescellular signaling |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Miliça Ristovski Danny Farhat Shelly Ellaine M. Bancud Jyh-Yeuan Lee |
spellingShingle |
Miliça Ristovski Danny Farhat Shelly Ellaine M. Bancud Jyh-Yeuan Lee Lipid Transporters Beam Signals from Cell Membranes Membranes P4-ATPase ABC transporter phospholipid cholesterol membranes cellular signaling |
author_facet |
Miliça Ristovski Danny Farhat Shelly Ellaine M. Bancud Jyh-Yeuan Lee |
author_sort |
Miliça Ristovski |
title |
Lipid Transporters Beam Signals from Cell Membranes |
title_short |
Lipid Transporters Beam Signals from Cell Membranes |
title_full |
Lipid Transporters Beam Signals from Cell Membranes |
title_fullStr |
Lipid Transporters Beam Signals from Cell Membranes |
title_full_unstemmed |
Lipid Transporters Beam Signals from Cell Membranes |
title_sort |
lipid transporters beam signals from cell membranes |
publisher |
MDPI AG |
series |
Membranes |
issn |
2077-0375 |
publishDate |
2021-07-01 |
description |
Lipid composition in cellular membranes plays an important role in maintaining the structural integrity of cells and in regulating cellular signaling that controls functions of both membrane-anchored and cytoplasmic proteins. ATP-dependent ABC and P4-ATPase lipid transporters, two integral membrane proteins, are known to contribute to lipid translocation across the lipid bilayers on the cellular membranes. In this review, we will highlight current knowledge about the role of cholesterol and phospholipids of cellular membranes in regulating cell signaling and how lipid transporters participate this process. |
topic |
P4-ATPase ABC transporter phospholipid cholesterol membranes cellular signaling |
url |
https://www.mdpi.com/2077-0375/11/8/562 |
work_keys_str_mv |
AT milicaristovski lipidtransportersbeamsignalsfromcellmembranes AT dannyfarhat lipidtransportersbeamsignalsfromcellmembranes AT shellyellainembancud lipidtransportersbeamsignalsfromcellmembranes AT jyhyeuanlee lipidtransportersbeamsignalsfromcellmembranes |
_version_ |
1721191725709393920 |