Lipid Transporters Beam Signals from Cell Membranes

Lipid composition in cellular membranes plays an important role in maintaining the structural integrity of cells and in regulating cellular signaling that controls functions of both membrane-anchored and cytoplasmic proteins. ATP-dependent ABC and P4-ATPase lipid transporters, two integral membrane...

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Main Authors: Miliça Ristovski, Danny Farhat, Shelly Ellaine M. Bancud, Jyh-Yeuan Lee
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Membranes
Subjects:
Online Access:https://www.mdpi.com/2077-0375/11/8/562
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spelling doaj-a284a6c7452445f084641aacc7097d4a2021-08-26T14:03:17ZengMDPI AGMembranes2077-03752021-07-011156256210.3390/membranes11080562Lipid Transporters Beam Signals from Cell MembranesMiliça Ristovski0Danny Farhat1Shelly Ellaine M. Bancud2Jyh-Yeuan Lee3Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaDepartment of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, CanadaLipid composition in cellular membranes plays an important role in maintaining the structural integrity of cells and in regulating cellular signaling that controls functions of both membrane-anchored and cytoplasmic proteins. ATP-dependent ABC and P4-ATPase lipid transporters, two integral membrane proteins, are known to contribute to lipid translocation across the lipid bilayers on the cellular membranes. In this review, we will highlight current knowledge about the role of cholesterol and phospholipids of cellular membranes in regulating cell signaling and how lipid transporters participate this process.https://www.mdpi.com/2077-0375/11/8/562P4-ATPaseABC transporterphospholipidcholesterolmembranescellular signaling
collection DOAJ
language English
format Article
sources DOAJ
author Miliça Ristovski
Danny Farhat
Shelly Ellaine M. Bancud
Jyh-Yeuan Lee
spellingShingle Miliça Ristovski
Danny Farhat
Shelly Ellaine M. Bancud
Jyh-Yeuan Lee
Lipid Transporters Beam Signals from Cell Membranes
Membranes
P4-ATPase
ABC transporter
phospholipid
cholesterol
membranes
cellular signaling
author_facet Miliça Ristovski
Danny Farhat
Shelly Ellaine M. Bancud
Jyh-Yeuan Lee
author_sort Miliça Ristovski
title Lipid Transporters Beam Signals from Cell Membranes
title_short Lipid Transporters Beam Signals from Cell Membranes
title_full Lipid Transporters Beam Signals from Cell Membranes
title_fullStr Lipid Transporters Beam Signals from Cell Membranes
title_full_unstemmed Lipid Transporters Beam Signals from Cell Membranes
title_sort lipid transporters beam signals from cell membranes
publisher MDPI AG
series Membranes
issn 2077-0375
publishDate 2021-07-01
description Lipid composition in cellular membranes plays an important role in maintaining the structural integrity of cells and in regulating cellular signaling that controls functions of both membrane-anchored and cytoplasmic proteins. ATP-dependent ABC and P4-ATPase lipid transporters, two integral membrane proteins, are known to contribute to lipid translocation across the lipid bilayers on the cellular membranes. In this review, we will highlight current knowledge about the role of cholesterol and phospholipids of cellular membranes in regulating cell signaling and how lipid transporters participate this process.
topic P4-ATPase
ABC transporter
phospholipid
cholesterol
membranes
cellular signaling
url https://www.mdpi.com/2077-0375/11/8/562
work_keys_str_mv AT milicaristovski lipidtransportersbeamsignalsfromcellmembranes
AT dannyfarhat lipidtransportersbeamsignalsfromcellmembranes
AT shellyellainembancud lipidtransportersbeamsignalsfromcellmembranes
AT jyhyeuanlee lipidtransportersbeamsignalsfromcellmembranes
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