Indoleamine 2,3-Dioxygenase 1 Inhibitor-Loaded Nanosheets Enhance CAR-T Cell Function in Esophageal Squamous Cell Carcinoma

Indoleamine 2,3-Dioxygenase 1 Inhibitor-Loaded Nanosheets Enhance CAR-T Cell Function in Esophageal Squamous Cell Carcinoma

In chimeric antigen receptor (CAR)-T cell therapy, the role and mechanism of indoleamine 2, 3 dioxygenase 1 (IDO1) in enhancing antitumor immunity require further study. IDO1 is one of the most important immunosuppressive proteins in esophageal squamous cell carcinoma (ESCC). However, the IDO1 inhib...

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Bibliographic Details
Main Authors: Jingwen Shao, Lin Hou, Jinyan Liu, Yulin Liu, Jie Ning, Qitai Zhao, Yi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
ESCC
combinatorial immunotherapy
IDO1
CAR-T
epacadostat
hyaluronic acid-modified nanomaterial graphene oxide
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.661357/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.661357/full

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