Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen

Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen

<p>Abstract</p> <p>Background</p> <p>Pharmacological high-throughput screening (HTS) represents a powerful strategy for drug discovery in genetic diseases, particularly when the full spectrum of pathological dysfunctions remains unclear, such as in Friedreich ataxia (FR...

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Bibliographic Details
Main Authors: Haiech Jacques, Hibert Marcel, Reutenauer Laurence, Villa Pascal, Seznec Hervé, Calmels Nadège, Rustin Pierre, Koenig Michel, Puccio Hélène
Format: Article
Language:English
Published: BMC 2009-08-01
Series:BMC Neurology
Online Access:http://www.biomedcentral.com/1471-2377/9/46

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