Dynamic Hepatocellular Carcinoma Model Within a Liver Phantom for Multimodality Imaging

Introduction: Hepatocellular carcinoma (HCC) is one of the most common cancer in the world, and the effectiveness of its treatment lies in its detection in its early stages. The aim of this study is to mimic HCC dynamically through a liver phantom and apply it in multimodality medical imaging techni...

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Main Authors: Muntaser S. Ahmad, Nursakinah Suardi, Ahmad Shukri, Nik Noor Ashikin Nik Ab Razak, Ammar A. Oglat, Osama Makhamrah, Hjouj Mohammad
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:European Journal of Radiology Open
Subjects:
HCC
CT
MRI
Online Access:http://www.sciencedirect.com/science/article/pii/S2352047720300460
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spelling doaj-a27327e5d24740039d9cbe7549302c7d2020-12-21T04:43:33ZengElsevierEuropean Journal of Radiology Open2352-04772020-01-017100257Dynamic Hepatocellular Carcinoma Model Within a Liver Phantom for Multimodality ImagingMuntaser S. Ahmad0Nursakinah Suardi1Ahmad Shukri2Nik Noor Ashikin Nik Ab Razak3Ammar A. Oglat4Osama Makhamrah5Hjouj Mohammad6School of Physics, Universiti Sains Malaysia, 11800, Penang, Malaysia; Corresponding author.School of Physics, Universiti Sains Malaysia, 11800, Penang, MalaysiaSchool of Physics, Universiti Sains Malaysia, 11800, Penang, MalaysiaSchool of Physics, Universiti Sains Malaysia, 11800, Penang, MalaysiaDepartment of Medical Imaging, Faculty of Applied Medical Sciences, Hashemite University, Zarqa, JordanMedical Imaging Department, Faculty of Health Professions, Al-Quds University, Jerusalem, PalestineMedical Imaging Department, Faculty of Health Professions, Al-Quds University, Jerusalem, PalestineIntroduction: Hepatocellular carcinoma (HCC) is one of the most common cancer in the world, and the effectiveness of its treatment lies in its detection in its early stages. The aim of this study is to mimic HCC dynamically through a liver phantom and apply it in multimodality medical imaging techniques including magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound. Methods and materials: The phantom is fabricated with two main parts, liver parenchyma and HCC inserts. The liver parenchyma was fabricated by adding 2.5 wt% of agarose powder combined with 2.6 wt% of wax powder while the basic material for the HCC samples was made from polyurethane solution combined with 5 wt% glycerol. Three HCC samples were inserted into the parenchyma by using three cylinders implanted inside the liver parenchyma. An automatic injector is attached to the input side of the cylinders and a suction device connected to the output side of the cylinders. After the phantom was prepared, the contrast materials were injected into the phantom and imaged using MRI, CT, and ultrasound. Results: Both HCC samples and liver parenchyma were clearly distinguished using the three imaging modalities: MRI, CT, and ultrasound. Doppler ultrasound was also applied through the HCC samples and the flow pattern was observed through the samples. Conclusion: A multimodal dynamic liver phantom, with HCC tumor models have been fabricated. This phantom helps to improve and develop different methods for detecting HCC in its early stages.http://www.sciencedirect.com/science/article/pii/S2352047720300460Liver phantomDynamic phantomHCCCTMRI
collection DOAJ
language English
format Article
sources DOAJ
author Muntaser S. Ahmad
Nursakinah Suardi
Ahmad Shukri
Nik Noor Ashikin Nik Ab Razak
Ammar A. Oglat
Osama Makhamrah
Hjouj Mohammad
spellingShingle Muntaser S. Ahmad
Nursakinah Suardi
Ahmad Shukri
Nik Noor Ashikin Nik Ab Razak
Ammar A. Oglat
Osama Makhamrah
Hjouj Mohammad
Dynamic Hepatocellular Carcinoma Model Within a Liver Phantom for Multimodality Imaging
European Journal of Radiology Open
Liver phantom
Dynamic phantom
HCC
CT
MRI
author_facet Muntaser S. Ahmad
Nursakinah Suardi
Ahmad Shukri
Nik Noor Ashikin Nik Ab Razak
Ammar A. Oglat
Osama Makhamrah
Hjouj Mohammad
author_sort Muntaser S. Ahmad
title Dynamic Hepatocellular Carcinoma Model Within a Liver Phantom for Multimodality Imaging
title_short Dynamic Hepatocellular Carcinoma Model Within a Liver Phantom for Multimodality Imaging
title_full Dynamic Hepatocellular Carcinoma Model Within a Liver Phantom for Multimodality Imaging
title_fullStr Dynamic Hepatocellular Carcinoma Model Within a Liver Phantom for Multimodality Imaging
title_full_unstemmed Dynamic Hepatocellular Carcinoma Model Within a Liver Phantom for Multimodality Imaging
title_sort dynamic hepatocellular carcinoma model within a liver phantom for multimodality imaging
publisher Elsevier
series European Journal of Radiology Open
issn 2352-0477
publishDate 2020-01-01
description Introduction: Hepatocellular carcinoma (HCC) is one of the most common cancer in the world, and the effectiveness of its treatment lies in its detection in its early stages. The aim of this study is to mimic HCC dynamically through a liver phantom and apply it in multimodality medical imaging techniques including magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound. Methods and materials: The phantom is fabricated with two main parts, liver parenchyma and HCC inserts. The liver parenchyma was fabricated by adding 2.5 wt% of agarose powder combined with 2.6 wt% of wax powder while the basic material for the HCC samples was made from polyurethane solution combined with 5 wt% glycerol. Three HCC samples were inserted into the parenchyma by using three cylinders implanted inside the liver parenchyma. An automatic injector is attached to the input side of the cylinders and a suction device connected to the output side of the cylinders. After the phantom was prepared, the contrast materials were injected into the phantom and imaged using MRI, CT, and ultrasound. Results: Both HCC samples and liver parenchyma were clearly distinguished using the three imaging modalities: MRI, CT, and ultrasound. Doppler ultrasound was also applied through the HCC samples and the flow pattern was observed through the samples. Conclusion: A multimodal dynamic liver phantom, with HCC tumor models have been fabricated. This phantom helps to improve and develop different methods for detecting HCC in its early stages.
topic Liver phantom
Dynamic phantom
HCC
CT
MRI
url http://www.sciencedirect.com/science/article/pii/S2352047720300460
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