FBW7 couples structural integrity with functional output of primary cilia

Petsouki et al. dissect the importance of FBW7-mediated regulation of NDE1 and TALPID3 in mesenchymal stem cells (MSCs). They find that by modulating the abundance of negative (NDE1) and positive (TALPID3) cilia regulators, FBW7 contributes to both the assembly and signaling functions of primary cil...

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Bibliographic Details
Main Authors: Eleni Petsouki, Vasileios Gerakopoulos, Nicholas Szeto, Wenhan Chang, Mary Beth Humphrey, Leonidas Tsiokas
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02504-4