Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

Abstract A phage‐derived human monoclonal antibody against VEGF‐C was developed as a potential anti‐tumor therapeutic and exhibited fast clearance in preclinical species, with notably faster clearance in serum than in plasma. The purpose of this work was to understand the factors contributing to its...

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Main Authors: Daniela Bumbaca Yadav, Arthur E. Reyes II, Priyanka Gupta, Jean‐Michel Vernes, Y. Gloria Meng, Michelle G. Schweiger, Shannon L. Stainton, Germaine Fuh, Paul J. Fielder, Amrita V. Kamath, Ben‐Quan Shen
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Pharmacology Research & Perspectives
Subjects:
immunocomplex
matrix effects
pharmacokinetics
VEGF‐C
Online Access:https://doi.org/10.1002/prp2.573

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