Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains

Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains

Chimeric antigen receptors (CAR) use antibody variable regions to activate anti-tumor immunity. Here the authors show that a mouse IgH/IgL variable region used in a clinical CAR induces host immune responses to possibly reduce therapy efficacy, but an IgH-only CAR T design achieves similar CAR T act...

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Main Authors: Norris Lam, Nathan D. Trinklein, Benjamin Buelow, George H. Patterson, Namrata Ojha, James N. Kochenderfer
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14119-9
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spelling doaj-a25f26915c1c45269a9ab2d9dfccb9982021-05-11T08:16:25ZengNature Publishing GroupNature Communications2041-17232020-01-0111111410.1038/s41467-019-14119-9Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domainsNorris Lam0Nathan D. Trinklein1Benjamin Buelow2George H. Patterson3Namrata Ojha4James N. Kochenderfer5National Institutes of Health, National Cancer Institute, Center for Cancer Research, Surgery BranchTeneoBio, Inc. 7999 Gateway BlvdTeneoBio, Inc. 7999 Gateway BlvdNational Institutes of Health, National Institute of Biomedical Imaging and BioengineeringNational Institutes of Health, National Institute of Biomedical Imaging and BioengineeringNational Institutes of Health, National Cancer Institute, Center for Cancer Research, Surgery BranchChimeric antigen receptors (CAR) use antibody variable regions to activate anti-tumor immunity. Here the authors show that a mouse IgH/IgL variable region used in a clinical CAR induces host immune responses to possibly reduce therapy efficacy, but an IgH-only CAR T design achieves similar CAR T activity but is potentially less immunogenic.https://doi.org/10.1038/s41467-019-14119-9
collection DOAJ
language English
format Article
sources DOAJ
author Norris Lam
Nathan D. Trinklein
Benjamin Buelow
George H. Patterson
Namrata Ojha
James N. Kochenderfer
spellingShingle Norris Lam
Nathan D. Trinklein
Benjamin Buelow
George H. Patterson
Namrata Ojha
James N. Kochenderfer
Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
Nature Communications
author_facet Norris Lam
Nathan D. Trinklein
Benjamin Buelow
George H. Patterson
Namrata Ojha
James N. Kochenderfer
author_sort Norris Lam
title Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
title_short Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
title_full Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
title_fullStr Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
title_full_unstemmed Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
title_sort anti-bcma chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-01-01
description Chimeric antigen receptors (CAR) use antibody variable regions to activate anti-tumor immunity. Here the authors show that a mouse IgH/IgL variable region used in a clinical CAR induces host immune responses to possibly reduce therapy efficacy, but an IgH-only CAR T design achieves similar CAR T activity but is potentially less immunogenic.
url https://doi.org/10.1038/s41467-019-14119-9
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AT benjaminbuelow antibcmachimericantigenreceptorswithfullyhumanheavychainonlyantigenrecognitiondomains
AT georgehpatterson antibcmachimericantigenreceptorswithfullyhumanheavychainonlyantigenrecognitiondomains
AT namrataojha antibcmachimericantigenreceptorswithfullyhumanheavychainonlyantigenrecognitiondomains
AT jamesnkochenderfer antibcmachimericantigenreceptorswithfullyhumanheavychainonlyantigenrecognitiondomains
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