Flavanones from Sorghum bicolor selectively inhibit COX-2: in-silico and in-vivo validation

Flavanones from Sorghum bicolor selectively inhibit COX-2: in-silico and in-vivo validation

Abstract Background COX-2-specific inhibitors offer improved advantages over traditional NSAIDs. Plants are known to play critical roles in the discovery and developments of new pharmaceuticals. To the best of our knowledge, nothing has been reported so far on the selective inhibition of the cycloox...

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Bibliographic Details
Main Authors: O. Adeboye Akinloye, D. Samuel Metibemu, D. Ibukun Akinloye, S. Bamidele Onigbinde, I. Abigail Olaosebikan, Ogunnowo Florence, Bashorun Damilola, O. Adeola Bolarinwa, Olaromilorun Olubunmi
Format: Article
Language:English
Published: SpringerOpen 2019-12-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Molecular docking
Virtual high throughput screening (vHTS)
Eriodictyol
Anti-inflammation
Cyclooxygenase-1 (COX-1)
Cyclooxygenase-2 (COX-2)
Online Access:https://doi.org/10.1186/s43042-019-0029-y

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