TNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C

TNFα PRODUCTION AND APOPTOSIS REGULATION IN VIRAL HEPATITIS TYPE C

Abstract. Chronical course of infection caused by hepatitis C virus is accompanied by increase Fas-positive lymphocytes of peripheral blood. Cultivation of agglutinin-stimulated mononuclear blood cells of patients with chronic hepatitis C revealed inhibition of apoptotic reactions of blood lymphocyt...

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Bibliographic Details
Main Authors: V. V. Novitsky, N. V. Rjazantseva, O. B. Zhukova, T. T. Radzivil, E. V. Beloborodova, A. P. Zima, I. O. Naslednikova, M. M. Litvak, S. L. Mikheev
Format: Article
Language:Russian
Published: SPb RAACI 2014-07-01
Series:Medicinskaâ Immunologiâ
Subjects:
hepatitis c virus
lymphocytes
apoptosis
tnfα
Online Access:https://www.mimmun.ru/mimmun/article/view/499
Description
Summary:Abstract. Chronical course of infection caused by hepatitis C virus is accompanied by increase Fas-positive lymphocytes of peripheral blood. Cultivation of agglutinin-stimulated mononuclear blood cells of patients with chronic hepatitis C revealed inhibition of apoptotic reactions of blood lymphocytes. This fact correlated with decrease in production of TNFα and accelerated synthesis of soluble receptor for this cytokine. We suggest a virus-specific influence on apoptosis regulation of target cells.
ISSN:1563-0625
2313-741X

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