Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

Induced pluripotent stem cell (iPSC) derived dopaminergic neurons are a promising source for cell-based Parkinson’s disease (PD) therapy. Here the authors report a comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC li...

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Main Authors:	Daisuke Doi, Hiroaki Magotani, Tetsuhiro Kikuchi, Megumi Ikeda, Satoe Hiramatsu, Kenji Yoshida, Naoki Amano, Masaki Nomura, Masafumi Umekage, Asuka Morizane, Jun Takahashi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17165-w

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spelling	doaj-a254d73774aa46918b7ca259baa03c3a2021-07-11T11:44:05ZengNature Publishing GroupNature Communications2041-17232020-07-0111111410.1038/s41467-020-17165-wPre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s diseaseDaisuke Doi0Hiroaki Magotani1Tetsuhiro Kikuchi2Megumi Ikeda3Satoe Hiramatsu4Kenji Yoshida5Naoki Amano6Masaki Nomura7Masafumi Umekage8Asuka Morizane9Jun Takahashi10Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityFacility for iPS Cell Therapy, Center for iPS Cell Research and Application, Kyoto UniversityFacility for iPS Cell Therapy, Center for iPS Cell Research and Application, Kyoto UniversityFacility for iPS Cell Therapy, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto UniversityInduced pluripotent stem cell (iPSC) derived dopaminergic neurons are a promising source for cell-based Parkinson’s disease (PD) therapy. Here the authors report a comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC line.https://doi.org/10.1038/s41467-020-17165-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Daisuke Doi Hiroaki Magotani Tetsuhiro Kikuchi Megumi Ikeda Satoe Hiramatsu Kenji Yoshida Naoki Amano Masaki Nomura Masafumi Umekage Asuka Morizane Jun Takahashi
spellingShingle	Daisuke Doi Hiroaki Magotani Tetsuhiro Kikuchi Megumi Ikeda Satoe Hiramatsu Kenji Yoshida Naoki Amano Masaki Nomura Masafumi Umekage Asuka Morizane Jun Takahashi Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease Nature Communications
author_facet	Daisuke Doi Hiroaki Magotani Tetsuhiro Kikuchi Megumi Ikeda Satoe Hiramatsu Kenji Yoshida Naoki Amano Masaki Nomura Masafumi Umekage Asuka Morizane Jun Takahashi
author_sort	Daisuke Doi
title	Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
title_short	Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
title_full	Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
title_fullStr	Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
title_full_unstemmed	Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
title_sort	pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for parkinson’s disease
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	Induced pluripotent stem cell (iPSC) derived dopaminergic neurons are a promising source for cell-based Parkinson’s disease (PD) therapy. Here the authors report a comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC line.
url	https://doi.org/10.1038/s41467-020-17165-w
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Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

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