Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia

Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia

Idiopathic hyperammonemia is a rare but potentially fatal complication occurring in patients with acute leukemia or bone marrow transplantation. The role of some specific anticancer drugs may be discussed, but the etiology of hyperammonemia is often multifactorial. We report the case of a 40-year-ol...

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Main Authors: Christophe Angelo, Marie-Françoise Vincent, Mina Komuta, Philippe Hantson, Nicole Straetmans, Edwige Boulet
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2020/3136074
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spelling doaj-a24ed0c1c2a64c2f8b7c7f8b1b1b26182020-11-25T02:36:23ZengHindawi LimitedCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/31360743136074Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid LeukemiaChristophe Angelo0Marie-Françoise Vincent1Mina Komuta2Philippe Hantson3Nicole Straetmans4Edwige Boulet5Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Clinical Chemistry, Cliniques St-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Pathology, Cliniques St-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Hematology, Cliniques St-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Hematology, Cliniques St-Luc, Université Catholique de Louvain, 1200 Brussels, BelgiumIdiopathic hyperammonemia is a rare but potentially fatal complication occurring in patients with acute leukemia or bone marrow transplantation. The role of some specific anticancer drugs may be discussed, but the etiology of hyperammonemia is often multifactorial. We report the case of a 40-year-old woman who developed fatal idiopathic hyperammonemia two weeks after induction chemotherapy with idarubicin-aracytine for acute myeloid leukemia. Despite intensive care management and extrarenal epuration, the patient was declared brain dead two days after hyperammonemia onset.http://dx.doi.org/10.1155/2020/3136074
collection DOAJ
language English
format Article
sources DOAJ
author Christophe Angelo
Marie-Françoise Vincent
Mina Komuta
Philippe Hantson
Nicole Straetmans
Edwige Boulet
spellingShingle Christophe Angelo
Marie-Françoise Vincent
Mina Komuta
Philippe Hantson
Nicole Straetmans
Edwige Boulet
Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia
Case Reports in Hematology
author_facet Christophe Angelo
Marie-Françoise Vincent
Mina Komuta
Philippe Hantson
Nicole Straetmans
Edwige Boulet
author_sort Christophe Angelo
title Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia
title_short Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia
title_full Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia
title_fullStr Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia
title_full_unstemmed Fatal Idiopathic Hyperammonemia after Induction Chemotherapy for Acute Myeloid Leukemia
title_sort fatal idiopathic hyperammonemia after induction chemotherapy for acute myeloid leukemia
publisher Hindawi Limited
series Case Reports in Hematology
issn 2090-6560
2090-6579
publishDate 2020-01-01
description Idiopathic hyperammonemia is a rare but potentially fatal complication occurring in patients with acute leukemia or bone marrow transplantation. The role of some specific anticancer drugs may be discussed, but the etiology of hyperammonemia is often multifactorial. We report the case of a 40-year-old woman who developed fatal idiopathic hyperammonemia two weeks after induction chemotherapy with idarubicin-aracytine for acute myeloid leukemia. Despite intensive care management and extrarenal epuration, the patient was declared brain dead two days after hyperammonemia onset.
url http://dx.doi.org/10.1155/2020/3136074
work_keys_str_mv AT christopheangelo fatalidiopathichyperammonemiaafterinductionchemotherapyforacutemyeloidleukemia
AT mariefrancoisevincent fatalidiopathichyperammonemiaafterinductionchemotherapyforacutemyeloidleukemia
AT minakomuta fatalidiopathichyperammonemiaafterinductionchemotherapyforacutemyeloidleukemia
AT philippehantson fatalidiopathichyperammonemiaafterinductionchemotherapyforacutemyeloidleukemia
AT nicolestraetmans fatalidiopathichyperammonemiaafterinductionchemotherapyforacutemyeloidleukemia
AT edwigeboulet fatalidiopathichyperammonemiaafterinductionchemotherapyforacutemyeloidleukemia
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