The functional role of long non-coding RNA in human carcinomas
<p>Abstract</p> <p>Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biol...
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| Format: | Article |
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2011-04-01
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| Series: | Molecular Cancer |
| Online Access: | http://www.molecular-cancer.com/content/10/1/38 |
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doaj-a24dee0bd53a4338a1068e0668f7f3d42020-11-25T01:32:11ZengBMCMolecular Cancer1476-45982011-04-011013810.1186/1476-4598-10-38The functional role of long non-coding RNA in human carcinomasBrown Carolyn JGibb Ewan ALam Wan L<p>Abstract</p> <p>Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.</p> http://www.molecular-cancer.com/content/10/1/38 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Brown Carolyn J Gibb Ewan A Lam Wan L |
| spellingShingle |
Brown Carolyn J Gibb Ewan A Lam Wan L The functional role of long non-coding RNA in human carcinomas Molecular Cancer |
| author_facet |
Brown Carolyn J Gibb Ewan A Lam Wan L |
| author_sort |
Brown Carolyn J |
| title |
The functional role of long non-coding RNA in human carcinomas |
| title_short |
The functional role of long non-coding RNA in human carcinomas |
| title_full |
The functional role of long non-coding RNA in human carcinomas |
| title_fullStr |
The functional role of long non-coding RNA in human carcinomas |
| title_full_unstemmed |
The functional role of long non-coding RNA in human carcinomas |
| title_sort |
functional role of long non-coding rna in human carcinomas |
| publisher |
BMC |
| series |
Molecular Cancer |
| issn |
1476-4598 |
| publishDate |
2011-04-01 |
| description |
<p>Abstract</p> <p>Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.</p> |
| url |
http://www.molecular-cancer.com/content/10/1/38 |
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1725082775022731264 |