Mitochondrial links between brain aging and Alzheimer’s disease

• Main Authors: Heather M. Wilkins, Russell H. Swerdlow
• Format: Article
• Language: English
• Published: BMC 2021-09-01
• Series: Translational Neurodegeneration
• Subjects: Aging; Alzheimer’s disease; Mitochondria; Mitochondrial DNA
• Online Access: https://doi.org/10.1186/s40035-021-00261-2

Abstract Advancing age is a major risk factor for Alzheimer’s disease (AD). This raises the question of whether AD biology mechanistically diverges from aging biology or alternatively represents exaggerated aging. Correlative and modeling studies can inform this question, but without a firm grasp of what drives aging and AD it is difficult to definitively resolve this quandary. This review speculates over the relevance of a particular hallmark of aging, mitochondrial function, to AD, and further provides background information that is pertinent to and provides perspective on this speculation.