Assessment of lipid metabolism in thyroid dysfunction

• Main Authors: V. G. Kadzharyan, A. I. Melnik, P. P. Bidzilya, S. A. Solovyuk
• Format: Article
• Language: English
• Published: Zaporozhye State Medical University 2014-02-01
• Series: Zaporožskij Medicinskij Žurnal
• Subjects: thyroid dysfunction; hypothyreosis; euthyreosis; condition of lipid metabolism.
• Online Access: http://zmj.zsmu.edu.ua/article/view/23657

1. Actuality According to WHO Thyroid dysfunction is one of the most prevalent in humans and is one of the risk factors of cardiovascular diseases. Hypothyroidism affects the mechanisms of potentiation of cardiovascular risk factors, suggesting the need to study the level of the blood lipids in all patients with thyroid dysfunction. 2. The purpose of this study. To define features of lipid metabolism, depending on the functional state of the thyroid gland. 3. Material and methods. The study included 95 patients, mean age was 49,8 ± 12,9 years. 74 of them were women (78%) and 21 - men (22%). In accordance with the purpose of the work 3 groups of subjects were formed. I-st group - 35 patients with hypothyroidism, mean age 52,5 ± 10,3 years, II-nd group - 37 patients with hyperthyroidism, the average age was 45,1 ± 13 years, III (control) group - 23 patients with euthyroid, mean age 53,9 ± 14,8 years. Levels of TSH, triiodothyronine, thyroxine, microsomal antibodies to thyroglobulin and thyroid peroxidase were evaluated for total and biochemical analysis. To determine the type of hyperlipoproteinemia Fredrickson, 1967 recommendations were used. 4. Results of the study Lipid profile parameters in the I-st group compared with the control were even higher. Cholesterol increased up to 6,9% (p <0,005), Tg - 8,6% (p <0,005), β -DP - 6,8% (p <0,5), in comparison with the II-nd: cholesterol - 56% (p <0,005), TG - 55% (p <0,005) and β-PL 44% (p <0.5). In group II rates were lower than in the III- cholesterol - 8% (p <0,005), Tg 8,3% (p <0,005) and β-PL 6,5% (p <0,5). Patients from the I-st group had the following distribution of hyperlipidemia (Fredrickson, 1967.): I type - 10 patients (29%); IIb type - 15 subjects (43%); IIa type - 9 subjects (26%); IV type - 1 patient (2%). The correlation dependence of TSH and cholesterol (r = +0,37, p <0,05), TG (r = +0,25, p <0,05), β-PL (r = +0,74, p <0.05), TG AT (r = +0,55, p <0,05), the level of bilirubin (r = +0,29, p <0,05), thymol (r = +0, 27, p <0,05), potassium (r = +0,26, p <0,05) and females (r = +0,20, p <0,05) was detected. 5. Findings 1. Hypothyroidism is accompanied by hypercholesterolemia, elevated triglycerides, elevated levels of low-density lipoproteins and the prevalence of type II hyperlipidemia. 2. Inhyperthyroidism is a reduction in cholesterol, triglycerides and low density lipoproteins. 3. The pathology of the thyroid gland causes the need for a differentiated approach to lipid-lowering therapy, taking into account the functional state of the body.