Hepatoprotectant Ursodeoxycholyl Lysophosphatidylethanolamide Increasing Phosphatidylcholine levels as a Potential Therapy of Acute Liver Injury

Hepatoprotectant Ursodeoxycholyl Lysophosphatidylethanolamide Increasing Phosphatidylcholine levels as a Potential Therapy of Acute Liver Injury

It has been long known that hepatic synthesis of phosphatidylchoine (PC) is depressed during acute such as carbon tetrachloride-induced liver injury. Anti-hepatotoxic properties of PC as liposomes have been recognized for treatment of acute liver damage. Ursodeoxycholate (UDCA) is a known hepatoprot...

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Bibliographic Details
Main Authors: Walee eChamulitrat, Wujuan eZhang, Weihong eXu, Anita ePathil, Kenneth eSetchell, Wolfgang eStremmel
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Physiology
Subjects:
Cytoprotection
Acute liver injury
bile acid-phospholipid conjugate
drug poisoning
PC homeostasis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00024/full

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