Comparative expression analysis of Shox2-deficient embryonic stem cell-derived sinoatrial node-like cells

Comparative expression analysis of Shox2-deficient embryonic stem cell-derived sinoatrial node-like cells

The homeodomain transcription factor Shox2 controls the development and function of the native cardiac pacemaker, the sinoatrial node (SAN). Moreover, SHOX2 mutations have been associated with cardiac arrhythmias in humans. For detailed examination of Shox2-dependent developmental mechanisms in SAN...

Full description

Bibliographic Details
Main Authors:	Sandra Hoffmann, Stefanie Schmitteckert, Anne Griesbeck, Hannes Preiss, Simon Sumer, Alexandra Rolletschek, Martin Granzow, Volker Eckstein, Beate Niesler, Gudrun A. Rappold
Format:	Article
Language:	English
Published:	Elsevier 2017-05-01
Series:	Stem Cell Research
Subjects:	Shox2 Mouse embryonic stem cells Transgenic cells Differentiation model Sinoatrial node-like cells
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506117300624

Similar Items

The Short-Stature Homeobox-Containing Gene (shox/SHOX) Is Required for the Regulation of Cell Proliferation and Bone Differentiation in Zebrafish Embryo and Human Mesenchymal Stem Cells
by: Tomoaki Yokokura, et al.
Published: (2017-06-01)

Murine transgenic embryonic stem cell lines for the investigation of sinoatrial node-related molecular pathways
by: Stefanie Schmitteckert, et al.
Published: (2017-12-01)

Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis
by: Marietta Easterling, et al.
Published: (2021-04-01)

Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other Genes
by: Sandra Hoffmann, et al.
Published: (2021-05-01)

Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial Fibrillation
by: Sandra Hoffmann, et al.
Published: (2019-07-01)

SHOX2 gene methylation in Egyptians having lung cancer
by: Mohamed Mostafa Mohamed Ahmed Rizk, et al.
Published: (2020-07-01)

Anatomical and clinical aspects of the blood supply of the sinoatrial node Aspectos clínicos e anatômicos da irrigação sanguínea do nó sinoatrial
by: A.C. Lopes, et al.
Published: (1998-03-01)

SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells
by: Chen, S., et al.
Published: (2022)

Heterozygous Deletion in Exons 4-5 of SHOX Gene in a Patient Diagnosed as Idiopathic Short Stature
by: David Anna, et al.
Published: (2017-09-01)

Large Deletions at the SHOX Locus in the Pseudoautosomal Region Are Associated with Skeletal Atavism in Shetland Ponies
by: Nima Rafati, et al.
Published: (2016-07-01)

Baixa Estatura e haploinsuficiência do gene SHOX
by: Mariana Costa, et al.
Published: (2016-03-01)

Phenotypic characterization of patients with deletions in the 3’-flanking SHOX region
by: Sarina G. Kant, et al.
Published: (2013-02-01)

Knee X-Ray in Short Stature: Helpful Indicator to Diagnose SHOX Deficiency
by: Partha Pratim Chakraborty, et al.
Published: (2017-01-01)

The Effect of Astragaloside on Pacemaker Current and the Cytoskeleton in Rabbit Sinoatrial Node Cells Under the Ischemia and Reperfusion Condition
by: Ruxiu Liu, et al.
Published: (2018-05-01)

SHOX deficiency in children with growth impairment: evaluation of known and new auxological and radiological indicators
by: Silvia Vannelli, et al.
Published: (2020-11-01)

CaMKII in sinoatrial node physiology and dysfunction
by: Yuejin eWu, et al.
Published: (2014-03-01)

Transcriptional and Epigenetic Landscape of Cardiac Pacemaker Cells: Insights Into Cellular Specialization in the Sinoatrial Node
by: Ravi Mandla, et al.
Published: (2021-07-01)

ANALYSIS OF GENE METHYLATION SHOX2, TGFBR1, MIR-375 IN DIFFERENT TYPES OF LUNG CANCER
by: D S Khodyrev, et al.
Published: (2016-12-01)

Características ultra-estruturais do nó sinoatrial de rato Wistar Superstructural features of the wistar strain male rats' sinoatrial node (SAN)
by: Carlos Alberto Mandarim de Lacerda, et al.
Published: (2002-04-01)

Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker
by: Rashid Minhas, et al.
Published: (2021-10-01)

Vascularização arterial da região do nó sinoatrial em corações suínos: origem, distribuição e quantificação Arterial vascularization of the sinoatrial node in swine hearts: origin, distribution and quantification
by: Ana P. Vidotti, et al.
Published: (2008-02-01)

Estudo do gene SHOX em pacientes com baixa estatura associada ou não a malformações esqueléticas encaminhadas com suspeita clínica da síndrome de Turner
by: SANTOS, Luana Oliveira dos
Published: (2015)

Overexpression of Shox2 Leads to Congenital Dysplasia of the Temporomandibular Joint in Mice
by: Xihai Li, et al.
Published: (2014-07-01)

Diagnostic Efficacy of SHOX2 Gene Hypermethylation for Lung Cancer: A Meta-Analysis
by: Qiang LIU, et al.
Published: (2021-07-01)

Curcumin can prevent the loss of sinoatrial node cells in methionine-treated rats: A stereological study
by: Atefeh Rahimi, et al.
Published: (2021-06-01)

Analysis of the Prognostic Value and Gene Expression Mechanism of SHOX2 in Lung Adenocarcinoma
by: Nanhong Li, et al.
Published: (2021-06-01)

E2A ablation enhances proportion of nodal-like cardiomyocytes in cardiac-specific differentiation of human embryonic stem cells
by: Xiuya Li, et al.
Published: (2021-09-01)

Mapping molecular pathways for embryonic Sertoli cells derivation based on differentiation model of mouse embryonic stem cells
by: Chenze Xu, et al.
Published: (2020-02-01)

Co-occurrence of genomic imbalances on Xp22.1 in the SHOX region and 15q25.2 in a girl with short stature, precocious puberty, urogenital malformations and bone anomalies
by: Alice Monzani, et al.
Published: (2019-01-01)

An Association of PTPN11 and SHOX Mutations in a Male Presenting With Syndromic Growth Failure
by: Emanuela Savarese, et al.
Published: (2018-09-01)

Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation
by: Chao-Shun Chan, et al.
Published: (2019-06-01)

SHOX2 is a Potent Independent Biomarker to Predict Survival of WHO Grade II–III Diffuse Gliomas
by: Yu-An Zhang, et al.
Published: (2016-11-01)

Chemically defined and small molecules-based generation of sinoatrial node-like cells
by: Fan, W., et al.
Published: (2022)

Unique Ca2+-Cycling Protein Abundance and Regulation Sustains Local Ca2+ Releases and Spontaneous Firing of Rabbit Sinoatrial Node Cells
by: Tatiana M. Vinogradova, et al.
Published: (2018-07-01)

Sinoatrial conduction abnormalities – an underestimated cardiac complication in women with systemic sclerosis
by: Elżbieta Kramarz, et al.
Published: (2021-05-01)

Detection of <italic>SHOX</italic> Gene Variations in Patients with Skeletal Abnormalities with or without Short Stature
by: Semra Gürsoy, et al.
Published: (2020-12-01)

Atrial and Sinoatrial Node Development in the Zebrafish Heart
by: Kendall E. Martin, et al.
Published: (2021-02-01)

Junctional Pacemaker May Replace the Sinoatrial Node
by: Min Lin, MD, et al.
Published: (2021-09-01)

Improved transgene expression in doxycycline-inducible embryonic stem cells by repeated chemical selection or cell sorting
by: Renáta Bencsik, et al.
Published: (2016-09-01)

Synchronization of Pacemaking in the Sinoatrial Node: A Mathematical Modeling Study
by: Daniel Gratz, et al.
Published: (2018-06-01)