Pharmacodynamic Evaluation of Shenfu Injection in Rats With Ischemic Heart Failure and Its Effect on Small Molecules Using Matrix-Assisted Laser Desorption/Ionization–Mass Spectrometry Imaging

Pharmacodynamic Evaluation of Shenfu Injection in Rats With Ischemic Heart Failure and Its Effect on Small Molecules Using Matrix-Assisted Laser Desorption/Ionization–Mass Spectrometry Imaging

Objectives: We aimed to evaluate the effect of Shenfu injection in a rat model of ischemic heart failure and explore its mechanism.Methods: A rat model of ischemic heart failure after myocardial infarction was established by ligating the left anterior descending coronary artery. Forty-eight hours af...

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Bibliographic Details
Main Authors:	Hao Wu, Zhenfeng Dai, Xi Liu, Ming Lin, Zeyu Gao, Fang Tian, Xin Zhao, Yi Sun, Xiaoping Pu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-11-01
Series:	Frontiers in Pharmacology
Subjects:	ischemic heart failure left anterior descending artery matrix-assisted laser desorption/ionization–mass spectrometry imaging phospholipid Shenfu injection
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2019.01424/full

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