Role of lipid transporters in fungal physiology and pathogenicity

• Main Authors: Juliana Rizzo, Lyubomir Dimitrov Stanchev, Vanessa K.A. da Silva, Leonardo Nimrichter, Thomas Günther Pomorski, Marcio L. Rodrigues
• Format: Article
• Language: English
• Published: Elsevier 2019-01-01
• Series: Computational and Structural Biotechnology Journal
• Online Access: http://www.sciencedirect.com/science/article/pii/S2001037019302557

The fungal cell wall and membrane are the most common targets of antifungal agents, but the potential of membrane lipid organization in regulating drug-target interactions has yet to be investigated. Energy-dependent lipid transporters have been recently associated with virulence and drug resistance in many pathogenic fungi. To illustrate this view, we discuss (i) the structural and biological aspects of ATP-driven lipid transporters, comprising P-type ATPases and ATP-binding cassette transporters, (ii) the role of these transporters in fungal physiology and virulence, and (iii) the potential of lipid transporters as targets for the development of novel antifungals. These recent observations indicate that the lipid-trafficking machinery in fungi is a promising target for studies on physiology, pathogenesis and drug development. Keywords: Flippases, ABC transporters, Fungal infections, Antifungals, Phosphatidylserine, Phosphatidylethanolamine, Sterols