Tryptophan and Kynurenine Pathway Metabolites in Animal Models of Retinal and Optic Nerve Damage: Different Dynamics of Changes

Tryptophan and Kynurenine Pathway Metabolites in Animal Models of Retinal and Optic Nerve Damage: Different Dynamics of Changes

Kynurenines, products of tryptophan (TRP) metabolism, display neurotoxic (e.g., 3-hydroxykynurenine; 3-HK), or neuroprotective (e.g., kynurenic acid; KYNA) properties. Imbalance between the enzymes constituting the kynurenine pathway (KP) plays a role in several disease, including neurodegeneration....

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Bibliographic Details
Main Authors: Michal Fiedorowicz, Tomasz Choragiewicz, Sebastian Thaler, Frank Schuettauf, Dominika Nowakowska, Kamila Wojtunik, Michele Reibaldi, Teresio Avitabile, Tomasz Kocki, Waldemar A. Turski, Agnieszka Kaminska, Pawel Grieb, Eberhart Zrenner, Robert Rejdak, Mario Damiano Toro
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Physiology
Subjects:
glaucoma
kynurenine pathway
tryptophan
retina
NMDA
optic nerve crush
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01254/full

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