Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting apoptosis.

Pterostilbene protects cochlea from ototoxicity in streptozotocin-induced diabetic rats by inhibiting apoptosis.

Diabetes mellitus (DM) causes ototoxicity by inducing oxidative stress, microangiopathy, and apoptosis in the cochlear sensory hair cells. The natural anti-oxidant pterostilbene (PTS) (trans-3,5-dimethoxy-4-hydroxystylbene) has been reported to relieve oxidative stress and apoptosis in DM, but its r...

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Bibliographic Details
Main Authors: Sibel Özdaş, Bora Taştekin, Seren G Gürgen, Talih Özdaş, Aykut Pelit, Sanem O Erkan, Birgül Tuhanioğlu, Birgül Gülnar, Orhan Görgülü
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228429

Internet

https://doi.org/10.1371/journal.pone.0228429

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