What’s in a loop?
<p>Abstract</p> <p>DNAs and proteins are major classes of biomolecules that differ in many aspects. However, a considerable number of their members also share a common architectural feature that enables the assembly of multi-protein complexes and thereby permits the effective proce...
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| Format: | Article |
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BMC
2012-10-01
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| Series: | Cell Communication and Signaling |
| Online Access: | http://www.biosignaling.com/content/10/1/31 |
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doaj-a2091db8713e44eca895b383600f49142020-11-24T21:07:12ZengBMCCell Communication and Signaling1478-811X2012-10-011013110.1186/1478-811X-10-31What’s in a loop?Feller Stephan MLewitzky Marc<p>Abstract</p> <p>DNAs and proteins are major classes of biomolecules that differ in many aspects. However, a considerable number of their members also share a common architectural feature that enables the assembly of multi-protein complexes and thereby permits the effective processing of signals: loop structures of substantial sizes. Here we briefly review a few representative examples and suggest a functional classification of different types of loop structures. In proteins, these loops occur in protein regions classified as intrinsically disordered. Studying such loops, their binders and their interactions with other loops should reveal much about cellular information computation and signaling network architectures. It is also expected to provide critical information for synthetic biologists and bioengineers.</p> http://www.biosignaling.com/content/10/1/31 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Feller Stephan M Lewitzky Marc |
| spellingShingle |
Feller Stephan M Lewitzky Marc What’s in a loop? Cell Communication and Signaling |
| author_facet |
Feller Stephan M Lewitzky Marc |
| author_sort |
Feller Stephan M |
| title |
What’s in a loop? |
| title_short |
What’s in a loop? |
| title_full |
What’s in a loop? |
| title_fullStr |
What’s in a loop? |
| title_full_unstemmed |
What’s in a loop? |
| title_sort |
what’s in a loop? |
| publisher |
BMC |
| series |
Cell Communication and Signaling |
| issn |
1478-811X |
| publishDate |
2012-10-01 |
| description |
<p>Abstract</p> <p>DNAs and proteins are major classes of biomolecules that differ in many aspects. However, a considerable number of their members also share a common architectural feature that enables the assembly of multi-protein complexes and thereby permits the effective processing of signals: loop structures of substantial sizes. Here we briefly review a few representative examples and suggest a functional classification of different types of loop structures. In proteins, these loops occur in protein regions classified as intrinsically disordered. Studying such loops, their binders and their interactions with other loops should reveal much about cellular information computation and signaling network architectures. It is also expected to provide critical information for synthetic biologists and bioengineers.</p> |
| url |
http://www.biosignaling.com/content/10/1/31 |
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