In vitro characterization of human bone marrow mesenchymal stem cell-derived motor neurons induced by epigenetic modifiers

In vitro characterization of human bone marrow mesenchymal stem cell-derived motor neurons induced by epigenetic modifiers

Abstract Background Motor neurons (MNs) are distinct types of cells in the dorso-ventral axis of the spinal cord. These cells are developed in the presence of two main morphogens, including Sonic hedgehog (Shh) and retinoic acid (RA). On the other hand, human bone marrow mesenchymal stem cells (hBM-...

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Bibliographic Details
Main Authors: Davood Sanooghi, Parham Vahdani, Zohreh Bagher, Faezeh Faghihi, Abolfazl Lotfi
Format: Article
Language:English
Published: SpringerOpen 2021-06-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Motor neuron
Bone marrow
Mesenchymal stem cell
Epigenetic
P300
EZH-2
Online Access:https://doi.org/10.1186/s43042-021-00171-y

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