Significant increase in plasma 4β-hydroxycholesterol concentration in patients after kidney transplantation

Significant increase in plasma 4β-hydroxycholesterol concentration in patients after kidney transplantation

Several previous studies have shown that renal failure decreases not only renal elimination but also metabolic clearance of drugs, particularly those metabolized by CYP3A. However, whether recovery of renal function results in recovery of hepatic CYP3A activity remains unknown. In this study, we eva...

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Bibliographic Details
Main Authors: Yosuke Suzuki, Hiroki Itoh, Fuminori Sato, Kanako Kawasaki, Yukie Sato, Takashi Fujioka, Yuhki Sato, Keiko Ohno, Hiromitsu Mimata, Satoshi Kishino
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Journal of Lipid Research
Subjects:
CYP3A activity
end-stage renal disease
renal failure
plasma
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520351452

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http://www.sciencedirect.com/science/article/pii/S0022227520351452

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