Ubiquitous expressed transcript promotes tumorigenesis by acting as a positive modulator of the polycomb repressive complex 2 in clear cell renal cell carcinoma

Ubiquitous expressed transcript promotes tumorigenesis by acting as a positive modulator of the polycomb repressive complex 2 in clear cell renal cell carcinoma

Abstract Background The ubiquitous expressed transcript (UXT) plays a key role in various tumors by regulating transcriptional activity of multiple transcription factors, including androgen receptor (AR). However, the role of UXT in clear cell renal cell carcinoma (ccRCC) is still unknown. Methods Y...

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Bibliographic Details
Main Authors: Jin Zeng, Wei Xiang, Yucong Zhang, Chunhua Huang, Ke Chen, Zhiqiang Chen
Format: Article
Language:English
Published: BMC 2019-09-01
Series:BMC Cancer
Subjects:
UXT
EZH2
PRC2
HMTase activity
ccRCC
Cell migration
Online Access:http://link.springer.com/article/10.1186/s12885-019-6069-3

Internet

http://link.springer.com/article/10.1186/s12885-019-6069-3

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