Diminished Expression of Corticotropin-Releasing Hormone Receptor 2 in Human Colon Cancer Promotes Tumor Growth and Epithelial-to-Mesenchymal Transition via Persistent Interleukin-6/Stat3 SignalingSummary

Diminished Expression of Corticotropin-Releasing Hormone Receptor 2 in Human Colon Cancer Promotes Tumor Growth and Epithelial-to-Mesenchymal Transition via Persistent Interleukin-6/Stat3 SignalingSummary

Background & Aims: Chronic inflammation promotes development and progression of colorectal cancer (CRC). We explored the distribution of the corticotropin-releasing-hormone (CRH) family of receptors and ligands in CRC and their contribution in tumor growth and oncogenic epithelial-to-mesenchymal...

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Bibliographic Details
Main Authors: Jorge A. Rodriguez, Sara Huerta-Yepez, Ivy Ka Man Law, Guillermina J. Baay-Guzman, Belen Tirado-Rodriguez, Jill M. Hoffman, Dimitrios Iliopoulos, Daniel W. Hommes, Hein W. Verspaget, Lin Chang, Charalabos Pothoulakis, Stavroula Baritaki
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X15001460

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