Effects of auricular point pressing + Danshen Dropping Pill on platelet function, inflammatory response and protease expression in patients with stable angina pectoris

• Main Authors: Chen-Ming Hu, Ji-Hong Liu, Yu Wu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-07-01
• Series: Journal of Hainan Medical University
• Subjects: Stable angina pectoris; Auricular point pressing; Platelet function; Inflammatory response; Protease expression
• Online Access: http://www.hnykdxxb.com/PDF/201813/03.pdf

Objective: To investigate the effects of auricular point pressing plus Danshen Dropping Pill on platelet function, inflammatory response and protease expression in patients with stable angina pectoris. Methods: A total of 92 patients with stable angina pectoris who were treated in this hospital between November 2014 and November 2017 were divided into the auricular point pressing group (n=46) and routine group (n=46) by random number table method. Routine group were treated with routine western medicine plus Danshen Dropping Pill, auricular point pressing group were treated with auricular point pressing on the basis of the therapy of routine group, and both groups had been continuously treated for 1 month. The differences in platelet function, inflammatory response and protease expression were compared between the two groups before and after treatment. Results: Before treatment, there was no statistically significant difference in the platelet activation index levels, serum inflammatory factor contents or protease expression between the two groups. After 1 month of treatment, peripheral blood platelet activation index CD42b level of auricular point pressing group was higher than that of routine group whereas CD63 and PAC-1 levels were lower than those of routine group; serum inflammatory factors IL-6, IL-10, IL-18 and hs-CRP contents were lower than those of routine group; serum proteases MMP-1, MMP-2 and MMP-9 contents were lower than those of routine group. Conclusion: Compound Danshen Dropping Pill combined with auricular point pressing can further optimize the platelet function and improve the systemic inflammatory state and protease expression in patients with stable angina pectoris.