Identification of SYS1 as a Host Factor Required for Shiga Toxin-Mediated Cytotoxicity in Vero Cells

Identification of SYS1 as a Host Factor Required for Shiga Toxin-Mediated Cytotoxicity in Vero Cells

Shiga toxin (STx) or Vero toxin is a virulence factor produced by enterohemorrhagic <i>Escherichia coli</i>. The toxin binds to the glycosphingolipid globotriaosylceramide (Gb3) for its entry, and causes cell death by inhibiting ribosome function. Previously, we performed a loss-of-funct...

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Bibliographic Details
Main Authors: Chisato Sakuma, Tsuyoshi Sekizuka, Makoto Kuroda, Kentaro Hanada, Toshiyuki Yamaji
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
glycosphingolipid
Vero
CRISPR/CAS9
genome-wide screening
Shiga toxin
SYS1
Online Access:https://www.mdpi.com/1422-0067/22/9/4936

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