A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation
Cullins are central components of the ubiquitin-proteosome system and are activated via a neddylation process mediated by the DCN1–UBC12 complex. Here, the authors develop a small molecule inhibitor of the DCN1–UBC12 interaction that specifically blocks cullin 3 neddylation and can be used to probe...
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Bibliographic Details
| Main Authors: |
Haibin Zhou,
Jianfeng Lu,
Liu Liu,
Denzil Bernard,
Chao-Yie Yang,
Ester Fernandez-Salas,
Krishnapriya Chinnaswamy,
Stephanie Layton,
Jeanne Stuckey,
Qing Yu,
Weihua Zhou,
Zhenqiang Pan,
Yi Sun,
Shaomeng Wang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2017-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-01243-7
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