Mycobacterial dynamin-like protein IniA mediates membrane fission

Tuberculosis drugs induce the expression of IniA, but so far little has been known about its structure and function. Here the authors present the apo and GTP bound crystal structures of Mycobacterium smegmatis IniA, which folds as a bacterial dynamin-like protein and show that IniA mediates membrane...

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Bibliographic Details
Main Authors: Manfu Wang, Xiangyang Guo, Xiuna Yang, Bing Zhang, Jie Ren, Aijun Liu, Yajun Ran, Bing Yan, Fang Chen, Luke W. Guddat, Junjie Hu, Jun Li, Zihe Rao
Format: Article
Language:English
Published: Nature Publishing Group 2019-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11860-z
Description
Summary:Tuberculosis drugs induce the expression of IniA, but so far little has been known about its structure and function. Here the authors present the apo and GTP bound crystal structures of Mycobacterium smegmatis IniA, which folds as a bacterial dynamin-like protein and show that IniA mediates membrane fission in vitro.
ISSN:2041-1723