PO-03 IMPROVEMENT IN POST-TRANSPLANT HYPERTENSION IN LIVING DONOR RENAL TRANSPLANTATION

• Main Authors: Ekamol Tantisattamo, Weera Sukhumthammarat, Prapaipan Putthapiban, Wasawat Vutthikraivit, Siwadon Pitukweerakul
• Format: Article
• Language: English
• Published: Atlantis Press 2016-11-01
• Series: Artery Research
• Online Access: https://www.atlantis-press.com/article/125930519/view

Objectives: Since genetic factor determines part of hypertensive phenotype, we aim to demonstrate the role of transplanted kidney from normotensive living donors in post-transplant hypertension (HTN). Methods: From 1.5-year-medical record review yielded 103 kidney transplant recipients in whom living-donor renal transplantation (LDRT) was performed in 32 (15 living-related renal transplantation (LRRT) and 17 living-unrelated renal transplantation (LURT)). Results: Of all 32 recipients, mean age was 51.30 years old (21.42–79.53) and 50% were male. Mean duration of follow-up was 8.4 months (0.63–16.33). Up to 93.75% of recipients had pre-transplant hypertension, and 56.25% became non-hypertensive after transplantation, which was defined as SBP≤140, DBP≤90, or being on≤2 BP agents regardless SBP or DBP (Figure 1). Mean post-transplant systolic blood pressure (SBP) was lower than pre-transplant SBP but not statistically significant (132.88+/−2.54 vs. 134.75+/−3.01, p= 0.6366) as same as mean DBP (77.84+/−1.88 vs. 82.25+/−2.39, p= 0.1520). The number of pre- and post-transplant blood pressure medications was 1.94 and 1.28, respectively. in LRRT group, 5 of 13 (38.46%) pre-transplant hypertensive patients became normotensive while 11 of 17 (64.71%) patients in LURT group were non-hypertensive(Figure 2). Mean post-transplant SBP was higher than mean pre-transplant SBP in LRRT group (1.33.73+/−3.33 vs. 129.67+/−4.40, p=0.4680); however, mean post-transplant DBP in LRRT group (77.93+/−2.68 vs. 79.40+/−3.20, p=0.7273) as well as mean SBP (132.12+/−3.85 vs. 139.24+/−3.93, p=0.2049) and mean DBP (77.76+/−2.71 vs. 84.76+/−3.48, p=0.1223) in LURT were lower than those during pre-transplant periods. The mean number of antihypertensive medications was decreased in post-transplant compared to pre-transplant in both LRRT (1+/−0.24 vs. 1.73+/−0.33, p=0.0844) and LURT (1.53+/−0.12 vs. 2.12+/−0.28, p=0.0616) groups. Conclusion: Hypertension was resolved in more than half of the pre-transplant hypertensive patients after kidney transplantation. Since higher number of LURT recipients becomes normotensive, the possibility of hypertensive genotype in living-related donor kidneys may contribute to post-transplant HTN in some LRRT recipients.