Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency

Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency

In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against...

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Main Authors: Sílvia Bacalhau, Cristina Freitas, Rosalina Valente, Deolinda Barata, Conceição Neves, Katrin Schäfer, Annelie Lubatschofski, Ansgar Schulz, João Farela Neves
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2011/527569
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spelling doaj-a1b97a51656f44c78649f75bd9fcbe8a2020-11-24T21:24:40ZengHindawi LimitedCase Reports in Medicine1687-96271687-96352011-01-01201110.1155/2011/527569527569Successful Handling of Disseminated BCG Disease in a Child with Severe Combined ImmunodeficiencySílvia Bacalhau0Cristina Freitas1Rosalina Valente2Deolinda Barata3Conceição Neves4Katrin Schäfer5Annelie Lubatschofski6Ansgar Schulz7João Farela Neves8Pediatric Intensive Care Unit, Hospital Dona Estefânia, 1169-045 Lisboa, PortugalPediatric Intensive Care Unit, Hospital Dona Estefânia, 1169-045 Lisboa, PortugalPediatric Intensive Care Unit, Hospital Dona Estefânia, 1169-045 Lisboa, PortugalPediatric Intensive Care Unit, Hospital Dona Estefânia, 1169-045 Lisboa, PortugalInfectology Unit, Hospital Dona Estefânia, Rua Jacinta Marto, 1169-045 Lisboa, PortugalDepartment of Immunology, Rheumatology and Stem Cell Transplantation, University Children's Hospital, 89073-89081 Ulm, GermanyDepartment of Immunology, Rheumatology and Stem Cell Transplantation, University Children's Hospital, 89073-89081 Ulm, GermanyDepartment of Immunology, Rheumatology and Stem Cell Transplantation, University Children's Hospital, 89073-89081 Ulm, GermanyInfectology Unit, Hospital Dona Estefânia, Rua Jacinta Marto, 1169-045 Lisboa, PortugalIn high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against tuberculosis should be redefined in non-high-burden countries. We report the case of a patient with X-linked severe combined immunodeficiency (SCID) who developed disseminated BCG disease, highlighting the specific strategies adopted.http://dx.doi.org/10.1155/2011/527569
collection DOAJ
language English
format Article
sources DOAJ
author Sílvia Bacalhau
Cristina Freitas
Rosalina Valente
Deolinda Barata
Conceição Neves
Katrin Schäfer
Annelie Lubatschofski
Ansgar Schulz
João Farela Neves
spellingShingle Sílvia Bacalhau
Cristina Freitas
Rosalina Valente
Deolinda Barata
Conceição Neves
Katrin Schäfer
Annelie Lubatschofski
Ansgar Schulz
João Farela Neves
Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency
Case Reports in Medicine
author_facet Sílvia Bacalhau
Cristina Freitas
Rosalina Valente
Deolinda Barata
Conceição Neves
Katrin Schäfer
Annelie Lubatschofski
Ansgar Schulz
João Farela Neves
author_sort Sílvia Bacalhau
title Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency
title_short Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency
title_full Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency
title_fullStr Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency
title_full_unstemmed Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency
title_sort successful handling of disseminated bcg disease in a child with severe combined immunodeficiency
publisher Hindawi Limited
series Case Reports in Medicine
issn 1687-9627
1687-9635
publishDate 2011-01-01
description In high-burden countries, Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine is administered in newborn to prevent severe Mycobacterium tuberculosis infection. Because life-threatening disseminated BCG disease may occur in children with primary immunodeficiency, vaccination strategy against tuberculosis should be redefined in non-high-burden countries. We report the case of a patient with X-linked severe combined immunodeficiency (SCID) who developed disseminated BCG disease, highlighting the specific strategies adopted.
url http://dx.doi.org/10.1155/2011/527569
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AT cristinafreitas successfulhandlingofdisseminatedbcgdiseaseinachildwithseverecombinedimmunodeficiency
AT rosalinavalente successfulhandlingofdisseminatedbcgdiseaseinachildwithseverecombinedimmunodeficiency
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