Metabolic Reprogramming and Inflammatory Response Induced by D-Lactate in Bovine Fibroblast-Like Synoviocytes Depends on HIF-1 Activity

Metabolic Reprogramming and Inflammatory Response Induced by D-Lactate in Bovine Fibroblast-Like Synoviocytes Depends on HIF-1 Activity

Acute ruminal acidosis (ARA) occurs after an excessive intake of rapidly fermentable carbohydrates and is characterized by the overproduction of D-lactate in the rumen that reaches the bloodstream. Lameness presentation, one of the primary consequences of ARA in cattle, is associated with the occurr...

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Bibliographic Details
Main Authors: John Quiroga, Pablo Alarcón, Carolina Manosalva, Stefanie Teuber, Anja Taubert, Carlos Hermosilla, María Angélica Hidalgo, María Daniella Carretta, Rafael Agustín Burgos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Veterinary Science
Subjects:
bovine fibroblast-like synoviocyte
D-lactate
metabolic reprogramming
inflammation
hypoxia inducible factor 1
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2021.625347/full

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https://www.frontiersin.org/articles/10.3389/fvets.2021.625347/full

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