A Bioinformatic Pipeline for Monitoring of the Mutational Stability of Viral Drug Targets with Deep-Sequencing Technology

A Bioinformatic Pipeline for Monitoring of the Mutational Stability of Viral Drug Targets with Deep-Sequencing Technology

The efficient development of antiviral drugs, including efficient antiviral small interfering RNAs (siRNAs), requires continuous monitoring of the strict correspondence between a drug and the related highly variable viral DNA/RNA target(s). Deep sequencing is able to provide an assessment of both th...

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Bibliographic Details
Main Authors: Yuri Kravatsky, Vladimir Chechetkin, Daria Fedoseeva, Maria Gorbacheva, Galina Kravatskaya, Olga Kretova, Nickolai Tchurikov
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Viruses
Subjects:
viruses
drug targets
mutations
deep-sequencing
data processing
bioinformatic pipeline
Online Access:https://www.mdpi.com/1999-4915/9/12/357

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