Mechanism of Action Potential Prolongation During Metabolic Inhibition in the Whole Rabbit Heart

Myocardial ischemia is associated with significant changes in action potential (AP) duration, which has a biphasic response to metabolic inhibition. Here, we investigated the mechanism of initial AP prolongation in whole Langendorff-perfused rabbit heart. We used glass microelectrodes to record APs...

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Bibliographic Details
Main Authors: Regina Mačianskienė, Irma Martišienė, Antanas Navalinskas, Rimantas Treinys, Inga Andriulė, Jonas Jurevičius
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01077/full