HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection

HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection

Tumor necrosis factor (TNF) is a key cytokine in HIV replication and pathogenesis. For reasons that are not entirely clear, the cytokine remains upregulated despite anti-retroviral therapy (ART). Here we demonstrate that HIV Nef induces an alternative TNF secretion mechanism that remains active in c...

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Bibliographic Details
Main Authors: Christian Ostalecki, Sebastian Wittki, Jung-Hyun Lee, Miriam M. Geist, Nadine Tibroni, Thomas Harrer, Gerold Schuler, Oliver T. Fackler, Andreas S. Baur
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:EBioMedicine
Subjects:
HIV Nef
ADAM17
Plasma extracellular vesicles
Endosomal secretion
Notch1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416304881

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http://www.sciencedirect.com/science/article/pii/S2352396416304881

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