Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction

Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction

Abstract Background The M2 phenotype of tumor-associated macrophages (TAM) inhibits the anti-tumor inflammation, increases angiogenesis and promotes tumor progression. The transcription factor Nuclear Factor (erythroid-derived 2)-Like 2 (Nrf2) not only modulates the angiogenesis but also plays the a...

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Bibliographic Details
Main Authors: Rui Feng, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Shuichi Iwahashi, Yu Saito, Mitsuo Shimada
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Cell Communication and Signaling
Subjects:
Nuclear factor (erythroid-derived 2)-like 2
Tumor-associated macrophage
Hepatocellular carcinoma
Pancreatic cancer
Epithelial-mesenchymal transition
Online Access:http://link.springer.com/article/10.1186/s12964-018-0262-x

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