Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

The mTOR complex 1 (mTORC1) and endoplasmic reticulum (ER) stress pathways are critical regulators of intestinal inflammation and colon cancer growth. Sestrins are stress-inducible proteins, which suppress both mTORC1 and ER stress; however, the role of Sestrins in colon physiology and tumorigenesis...

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Bibliographic Details
Main Authors: Seung-Hyun Ro, Xiang Xue, Sadeesh K Ramakrishnan, Chun-Seok Cho, Sim Namkoong, Insook Jang, Ian A Semple, Allison Ho, Hwan-Woo Park, Yatrik M Shah, Jun Hee Lee
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
Sestrin2
colitis
colon cancer
tumor suppressor
p53
Online Access:https://elifesciences.org/articles/12204

Internet

https://elifesciences.org/articles/12204

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