Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements

Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements

Summary: Sodium nitroprusside–enhanced cardiopulmonary resuscitation has shown superior resuscitation rates and neurologic outcomes in large animal models supporting the need for a randomized human clinical trial. This study is the first to show nonselective pulmonary vasodilation as a potential mec...

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Main Authors: Adrian Ripeckyj, BA, Marinos Kosmopoulos, MD, Kadambari Shekar, MS, Claire Carlson, DO, Rajat Kalra, MD, Jennifer Rees, PhD, Tom P. Aufderheide, MD, MS, Jason A. Bartos, MD, PhD, Demetris Yannopoulos, MD
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19304103
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spelling doaj-a19d8f57a9df40d2ba5e035c9a0646562020-11-25T01:10:36ZengElsevierJACC: Basic to Translational Science2452-302X2020-02-0152183192Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen RequirementsAdrian Ripeckyj, BA0Marinos Kosmopoulos, MD1Kadambari Shekar, MS2Claire Carlson, DO3Rajat Kalra, MD4Jennifer Rees, PhD5Tom P. Aufderheide, MD, MS6Jason A. Bartos, MD, PhD7Demetris Yannopoulos, MD8Cardiovascular Division, University of Minnesota, Minneapolis, MinnesotaCardiovascular Division, University of Minnesota, Minneapolis, MinnesotaCardiovascular Division, University of Minnesota, Minneapolis, MinnesotaCardiovascular Division, University of Minnesota, Minneapolis, MinnesotaCardiovascular Division, University of Minnesota, Minneapolis, MinnesotaCardiovascular Division, University of Minnesota, Minneapolis, MinnesotaDepartment of Emergency Medicine, Medical College of Wisconsin, Milwaukee, WisconsinCardiovascular Division, University of Minnesota, Minneapolis, Minnesota; Center for Resuscitation Medicine, University of Minnesota School of Medicine, Minneapolis, MinnesotaCardiovascular Division, University of Minnesota, Minneapolis, Minnesota; Center for Resuscitation Medicine, University of Minnesota School of Medicine, Minneapolis, Minnesota; Address for correspondence: Dr. Demetris Yannopoulos, Center for Resuscitation Medicine, Office of Academic Clinical Affairs, University of Minnesota Medical School, 420 Delaware Street, Southeast, MMC 508 Mayo, Minneapolis, Minnesota 55455.Summary: Sodium nitroprusside–enhanced cardiopulmonary resuscitation has shown superior resuscitation rates and neurologic outcomes in large animal models supporting the need for a randomized human clinical trial. This study is the first to show nonselective pulmonary vasodilation as a potential mechanism for the hemodynamic benefits. The pulmonary shunting that is created requires increased oxygen treatment, but the overall improvement in blood flow increases minute oxygen delivery to tissues. In this context, hypoxemia is an important safety endpoint and a 100% oxygen ventilation strategy may be necessary for the first human clinical trial. Key Words: cardiopulmonary resuscitation, coronary perfusion pressure, lactic acid, pulmonary vasodilation, sodium nitroprussidehttp://www.sciencedirect.com/science/article/pii/S2452302X19304103
collection DOAJ
language English
format Article
sources DOAJ
author Adrian Ripeckyj, BA
Marinos Kosmopoulos, MD
Kadambari Shekar, MS
Claire Carlson, DO
Rajat Kalra, MD
Jennifer Rees, PhD
Tom P. Aufderheide, MD, MS
Jason A. Bartos, MD, PhD
Demetris Yannopoulos, MD
spellingShingle Adrian Ripeckyj, BA
Marinos Kosmopoulos, MD
Kadambari Shekar, MS
Claire Carlson, DO
Rajat Kalra, MD
Jennifer Rees, PhD
Tom P. Aufderheide, MD, MS
Jason A. Bartos, MD, PhD
Demetris Yannopoulos, MD
Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements
JACC: Basic to Translational Science
author_facet Adrian Ripeckyj, BA
Marinos Kosmopoulos, MD
Kadambari Shekar, MS
Claire Carlson, DO
Rajat Kalra, MD
Jennifer Rees, PhD
Tom P. Aufderheide, MD, MS
Jason A. Bartos, MD, PhD
Demetris Yannopoulos, MD
author_sort Adrian Ripeckyj, BA
title Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements
title_short Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements
title_full Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements
title_fullStr Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements
title_full_unstemmed Sodium Nitroprusside–Enhanced Cardiopulmonary Resuscitation Improves Blood Flow by Pulmonary Vasodilation Leading to Higher Oxygen Requirements
title_sort sodium nitroprusside–enhanced cardiopulmonary resuscitation improves blood flow by pulmonary vasodilation leading to higher oxygen requirements
publisher Elsevier
series JACC: Basic to Translational Science
issn 2452-302X
publishDate 2020-02-01
description Summary: Sodium nitroprusside–enhanced cardiopulmonary resuscitation has shown superior resuscitation rates and neurologic outcomes in large animal models supporting the need for a randomized human clinical trial. This study is the first to show nonselective pulmonary vasodilation as a potential mechanism for the hemodynamic benefits. The pulmonary shunting that is created requires increased oxygen treatment, but the overall improvement in blood flow increases minute oxygen delivery to tissues. In this context, hypoxemia is an important safety endpoint and a 100% oxygen ventilation strategy may be necessary for the first human clinical trial. Key Words: cardiopulmonary resuscitation, coronary perfusion pressure, lactic acid, pulmonary vasodilation, sodium nitroprusside
url http://www.sciencedirect.com/science/article/pii/S2452302X19304103
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