Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca+2 Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells

Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca+2 Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells

Breast cancer is the most heterogenous cancer type among women across the world. Despite concerted efforts, breast cancer management is still unsatisfactory. Interplay between apoptosis and autophagy is an imperative factor in categorizing therapeutics for cancer treatment. Proscillaridin A (PSD-A),...

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Bibliographic Details
Main Authors: Muhammad Zubair Saleem, Mohammed Alshwmi, He Zhang, Syed Riaz Ud Din, Muhammad Azhar Nisar, Muhammad Khan, Shahid Alam, Gulzar Alam, Lingling Jin, Tonghui Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
proscillaridin A
apoptosis
autophagy
signal transducer and activator of transcription 3 (STAT3)
c-Jun N-terminal kinase
breast cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01055/full

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