Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits.

Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits.

In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48,...

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Main Authors: Geneviève Jolivet, Sandrine Braud, Bruno DaSilva, Bruno Passet, Erwana Harscoët, Céline Viglietta, Thomas Gautier, Laurent Lagrost, Nathalie Daniel-Carlier, Louis-Marie Houdebine, Itzik Harosh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4162549?pdf=render

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