D2-Like Receptors Mediate Dopamine-Inhibited Insulin Secretion via Ion Channels in Rat Pancreatic β-Cells

D2-Like Receptors Mediate Dopamine-Inhibited Insulin Secretion via Ion Channels in Rat Pancreatic β-Cells

Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data from the radioimmunoassay indicated that dopa...

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Bibliographic Details
Main Authors: Mengmeng Liu, Lele Ren, Xiangqin Zhong, Yaqin Ding, Tao Liu, Zhihong Liu, Xiaohua Yang, Lijuan Cui, Lijun Yang, Yanying Fan, Yunfeng Liu, Yi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Endocrinology
Subjects:
dopamine
D2-like receptors
insulin secretion
KV channels
Ca2+ channels
β cells
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00152/full

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