Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice

Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice

AimGuanidinoacetate N-methyltransferase (GAMT) is the second essential enzyme in creatine (Cr) biosynthesis. Short-term Cr deficiency is metabolically well tolerated as GAMT–/– mice exhibit normal exercise capacity and response to ischemic heart failure. However, we hypothesized long-term consequenc...

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Bibliographic Details
Main Authors: Dunja Aksentijević, Sevasti Zervou, Thomas R. Eykyn, Debra J. McAndrew, Julie Wallis, Jurgen E. Schneider, Stefan Neubauer, Craig A. Lygate
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Physiology
Subjects:
cardiac energetics
creatine
energy metabolism
mitochondrial respiration
ventricular function
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01535/full

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